UPLC-Q-TOF/MS-based metabolic profiles of wogonoside by intestinal bacteria / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4024-4028, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-852494
ABSTRACT
Objective To investigate the metabolic effects of wogonoside by human gut microbiota. Methods UPLC-Q-TOF/MS was used to analyze the metabolites of wogonoside. Additionally, 16 S rDNA molecular biology method was applied to the identification and composition analysis of intestinal bacteria. Results Wogonoside was mainly metabolized to wogonin and small quantities of demethylated metabolites. Most of Enterococcus and Escherchia had the metabolic abilities, among which a single bacterium Escherichia sp. 41 possessed the stronger metabolic activity. Conclusion This study has a good guiding significance for in vivo process and efficacy of wogonoside.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2017
Type:
Article
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