Lanostane triterpenoids of Ganoderma lucidum and their inhibitory effect on α-glucosidase / 中草药
Chinese Traditional and Herbal Drugs
; (24): 1275-1281, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-852864
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective: To study the chemical constituents from the dried fruiting body of Ganoderma lucidum and its activities. Methods: The compounds were isolated and purified from the 95% ethanol extract of G. lucidum by silica gel CC, MPLC, HPLC, and so on. Their structures were identified by extensive spectroscopic analysis. The compounds were evaluated for their inhibitory effects against α-glucosidase compared with those of the positive control acarbose. Results: A total of 11 lanostane triterpenoids were isolated from the 95% ethanol extract of G. lucidum and identified as ganoderanol A (1), ganoderic acid H (2), ganoderic acid AM1 (3), ganoderic acid D (4), methyl ganoderate D (5), ganolucidic acid E (6), 11α-hydroxy-3,7-dioxo-5α-lanosta-8,24 (E)-dien-26-oic acid (7), ganoderenic acid D (8), lucidenic acid A (9), methyl lucidenate F (10), and lucidenic acid B (11). Conclusion: Among them, compound 1 is a new compound. Additionally, compounds 1 and 5 show moderate inhibitory effect on α-glucosidase.
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2017
Type:
Article