Study on daphnane diterpenoids of Trigonostemon lutescens / 中草药

ABSTRACT

Objective: To study the daphnane diterpenoids of Trigonostemon lutescens form Guangxi province. Methods: The ethanol extract of T. lutescens was separated and purified by column chromatography, and the structures of the compounds were identified by physicochemical properties and spectral data. Results: Twelve daphnane diterpenoids were separated and identified form T. lutescens as trigoxyphin A (1), 3,16α-dihydroxy-kaurane (2), entkaurane-3,16α-diol (3), 10,16α-dihydroxy-isokaurane (4), entkaurane-3, 5,16α-triol (5), 8α-hydroxy-3,4-secopimara-4,15(18)-diene-3-oic acid (6), 8α-hydroxy-3,4-secopimara-4,15(18)-diene-3-oate (7), 3,4-secopimara-4,8(9),15(18)-triene-3-acid-methyl ester (8), trigoflavidone A (9), clerodane-2,4,11-triene-17-acid methyl ester (10), 3α-dihydroxy-kaurane-16-ene (11), and 13α-dihydroxy-kaurane-16-ene-18-acid methyl ester (12). Conclusion: All these daphnane diterpenoids are first separated and identified form T. lutescens.