Comparation on effect between Phellodendri Chinensis Cortex and Coptis Rhizoma on organism metabolism in mice / 中草药

ABSTRACT

Objective: To compare the effect of Phellodendri Chinensis Cortex (HB) and Coptis Rhizoma (HL) on organism metabolism in mice and explore the regulation of both HB and HL on the endogenous metabolism in mice. Methods: 1H-NMR, based on metabolomic approach coupled with multivariate statistical analysis method, was used to investigate the intervention differences between HB and HL on endogenous metabolites in the serum and liver of normal mice after drug administration. Results: The changes of organism endogenous metabolites in both HB and HL treated groups were similar, but the differences also existed. Compared with the control group, the levels of 3-HB, NAG, glycerin, choline, α-glucose,and β-glucose in serum and those of glutamate, glycogen, adenosine, GSSG, betaine, and other metabolites in liver were changed in the two drug treated groups in a different change range. These changes of endogenous metabolites involved in glycometabolism, lipid metabolism, and other pathways. Conclusion: This study provides a scientific basis for the comparative analysis of drug function between HB and HL, which has both the similarities and differences.