Clinical observation on Xueshuantong Injection in treatment of acute cerebral infarction patients with Clopidogrel resistance / 中草药

ABSTRACT

Objective: To observe the effect of Xueshuantong Injection on platelet aggregation in acute cerebral infarction patients with Clopidogrel resistance (CR). Methods: This study selected acute cerebral infarction patients with CR from March 2012 to August 2014 in Tianjin Hospital. Patients (104 cases) were randomly divided into two groups (n = 52). The patients in the control group were treated with Western Medicine and Clopidogrel 75 mg/d, and the patients in treatment group were treated with Western Medicine and Clopidogrel 75 mg/d and given Xueshuantong Injection (5 mL dissolved in 0.9% saline 250 mL, iv drip). The two groups were treated for 14 d. Results: The platelet aggregation in the two groups was reduced significantly after treatment (P < 0.05), and after treatment the platelet aggregation in the treatment group was lower than that in the control group (P < 0.05). Conclusion: Xueshuantong Injection can reduce platelet aggregation in acute cerebral infarction patients with CR, and is a beneficial supplement therapy for CR.