Observation on pharmacological and clinical effects of Liangxue Huaban Granule in treatment of psoriasis / 中草药

ABSTRACT

Objective: To investigate the pharmacological and clinical effects of Liangxue Huaban Granule in the treatment of psoriasis. Methods: The models of vaginal epithelium cell mitosis and scaled tail epidermis in mice with estrogen cycle were used to observe the changes of mice after administration of Liangxue Huaban Granule so as to study its pharmacological effects. Meanwhile, 100 cases of patients with psoriasis were chosen and randomly divided into two groups, treatment group and control group, there were 50 cases in each group respectively. The patients in the treatment group were given Liangxue Huaban Granule orally, one bag each time and three times daily. The patients in the control group were given the decoction of Liangxue Huaban components orally, one dose with decocting water, half dose in the morning and evening, respectively. Both two groups had four months treatment, six months post visiting, in order to observe and compare the effects of the two groups and PASI grades which were statistically analyzed by SPSS 19.0. Results: Liangxue Huaban Granule could inhibit the mitosis of mouse vaginal epithelia and promote the formation of cuticular granular cells on scaled epidemis of mouse tail. In the clinical observation, the total effective rates in the treatment group and the control group are 88.00% and 90.00%, respectively. And there is no significant difference in lowering the severity index of psoriasis (PASI grades) and curative effect index between two groups. Conclusion: The Liangxue Huaban Granule can effectively improve and reverse the pathological model of psoriasis in mice. It has the definite clinical effects of curing psoriasis, And it is convenient to take and has stable quality. In addition, Liangxue Huaban Granule has certain clinical application value.