Sesquiterpenoids from branches and leaves of Cephalotaxus lanceolata / 中草药

ABSTRACT

Objective: To isolate and identify the chemical constituents from the branches and leaves of Cephalotaxus lanceolata. Methods: The compounds were separated and purified by column chromatography with silica gel, Sephadex LH-20, MPLC, and HPLC. Their structures were elucidated on the basis of spectroscopic methods. Results: Eleven sesquiterpenoids were isolated from 95% ethanol extract of the branches and leaves of C. lanceolata and identified as lanceoloside A (1), lanceoloside B (2), lanceoloside C (3), 9-hydroxy-4,7-megastigmadien-3-one (4), corchoionol C (5), 9,10-dihydroxy-4,7-megastigmadien-3-one (6), 5,12-epoxy-9- hydroxy-7-megastigmen-3-one (7), 5,12-epoxy-6,9-hydroxy-7-megastigmen-3-one (8), loliolide (9), (3S,5R,8S)-5,8-epoxy-6- megastigmadien-3,9-diol (10), and clovandiol (11) respectively. Conclusion: Compounds 1 is identified as a new sesquiterpenoid, while compounds 2-3 are two new natural products. Compounds 4-11 are isolated from this plant for the first time.