Preparation of Sanqi Hydrogel Patch used for setting a bone and study on its transdermal permeability in vitro / 中草药

ABSTRACT

To prepare Sanqi Hydrogel Patch used for setting a bone and study its transdermal permeation properties in vitro. In this paper, the appearance description, initial bonding strength, endurance bonding strength, and peel strength were taken as indexes. Based on the result of a single factor experiment, the formula for the Sanqi Hydrogel Patch was optimized by central composite design-response surface methodology. Franz diffusing cells method was chosen to study its transdermal permeability in vitro with asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 as index components. The optimal ratio of the prescription was as follows ViscomateTM NP700-Carbomer 940-PVPK90-kaoline-dihydroxyaluminum aminoacetate (1.86∶1.48∶0.49∶0.5∶0.16). Within 24 h, the transdermal rates of asperosaponin VI, ginsenoside Rg1, ginsenoside Rb1, and notoginsenoside R1 were 1.868, 4.233, 1.149, and 1.558 μ g/(cm2∙h). Sanqi Hydrogel Patch has a better release and transdermal properties and the transdermal actions are consistent with zero-order kinetics.