Effect of Xueshuantong Injection on platelet function of rabbits with hyperlipemia / 中草药

ABSTRACT

Objective: To investigate the effect of Xueshuantong Injection (lyophilized, main constituents are total saponins of Panax notoginseng with content of 95%) on the platelet function of rabbits with hyperlipemia. Methods: The model was made by giving the food with high fat to rabbits for 2 weeks, then Xueshuantong Injection (6.25, 12.50, and 25.00 mg/kg) was iv given once daily for 14 d and the function of platelet was tested after preparing serum and plasma by taking blood form carotid artery. Results: Xueshuantong Injection could reduce blood lipid levels, inhibit the platelet aggregation induced by ADP, AA, & COLL, and reduce the aggregation curve slope & the aggregation delay; lower the expression levels of VCAM-1, PF4, and P-selectin; prolong the APTT, and decrease the level of FIB. Conclusion: Xueshuantong injection (lyophilized) has the anti-aggregation function.