Study on "heat by heat gain" effect of wine-broiled Curculigo orchioides / 中草药

ABSTRACT

Objective: To compare the thermal resistance of Curculigo orchioides and wine-broiled C. orchioides by pharmaco- dynamic index, and to explore the processing principle "heat by heat gain" of wine-broiled C. orchioides. Methods: The "heat" influence of raw C. orchioides and processing principle "heat by heat gain" of wine-broiled C. orchioides were determined by comparing the effects of raw and processed C. orchioides on 16 kinds of indicators in the serum of model rats with kidney Yang deficiency-cold syndrome induced by hydrocortisone, such as adrenaline (Adr), norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), cAMP/cGMP value, three iodine thyronine (T3), four iodine thyronine (T4), thyroid stimulating hormone (TSH), testosterone (Ts), Na+, K+-ATP enzyme, glucose (Glu), total cholesterol (TC), total protein (TP), and triglyceride (TG). Results: The raw C. orchioides effectively reduced the contents of triglycerides and cGMP, and improved the 14 indicators in the serum of model rats with kidney Yang deficiency-cold syndrome induced by hydrocortisone, such as Adr, NE, DA, 5-HT, cAMP, T3, T4, TSH, Ts, Na+, K+-ATP enzyme, Glu, TC, TP, and the ratio of cAMP/cGMP. The effects of wine-broiled C. orchioides on increasing 12 indexes such as Adr, NE, 5-HT, cAMP, T3, T4, TSH, Ts, Na+, K+-ATP enzyme, Glu, TC, and TP were more significant with obvious differences (P < 0.05, 0.01) than the raw C. orchioides group. Conclusion: The "heat" influence of C. orchioides is enhanced after broiled by wine, and the processing principle "heat by heat gain" has been established. The "heat" influence is impoved by enhancing the material energy metabolism, improving the functions of the central neurotransmitter and pituitary-adrenal axis, cyclic nucleotide level, and target axis.