Preparation and characterization of micronized trans-cinnamic acid by anti-solvent crystallization method / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2165-2171, 2014.
Article
Dans Chinois
| WPRIM
| ID: wpr-854745
ABSTRACT
Objective:
Using ethanol as solvent, deionized water as anti-solvent, and HPMC as the surfactant, to prepare trans-cinnamic acid (TCA) micro powder by single factor analysis. The effects of five experimental parameters on the mean particle size (MPS) and morphology of TCA nanosuspension were investigated.Methods:
Transmission electron microscope (TEM), laser granulometric analysis, Fourier transform infrared spectroscopy (FTIR), high performance liquid chromatography-mass spectrometry (LC-MS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and dissolution were used to analyze the characteristic of micronized TCA nanosuspension.Results:
The micronized TCA with an MPS of 130 nm was obtained under the optimum conditions. The dissolution rate of TCA nanosuspension was 1.67 times of raw drug.Conclusion:
Using anti-solvent recrystallization to prepare micronized TCA can improve the solubility and dispersion of TCA nanosuspension in water, and they provide the basis for further formulation development.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2014
Type:
Article
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