Formula optimization of andrographolide-loaded PLGA microsphere by Box-Behnken design and response surface method / 中草药
Chinese Traditional and Herbal Drugs
; (24): 1743-1747, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-855249
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective: To optimize the formula of andrographolide-loaded PLGA microsphere. Methods: The microspheres were prepared by the solvent evaporation method using PLGA as drug carriers. The effects of the concentration of PLGA and PVA, and the oil-water phase ratio were investigated. According to the drug loading amount and encapsulation efficiency, the formula was optimized by Box-Behnken design and response surface method. Results: The optimal formula was as follows: PLGA concentration of 0.20 g/mL, PVA concentration of 18 mg/mL, and oil-water phase ratio of 1:90, respectively. The drug loading amount of the microsphere was (47.21 ± 2.36)% and the encapsulation efficiency was (90.15 ± 3.48)%, which were very close to the predicted values. Conclusion: It is effective and feasible to apply Box-Behnken design and response surface method for the formula optimization of the andrographolide-loaded PLGA microsphere.
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Indice:
WPRIM
langue:
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Texte intégral:
Chinese Traditional and Herbal Drugs
Année:
2013
Type:
Article