Antigout active fractions in Tongfeng Granule / 中草药

ABSTRACT

Objective: To observe the therapeutic effect of the various active fractions in Tongfeng Granule on gouty arthritis, gouty hyperuricemia with renal protection. Methods: The swelling models of ankle and voix pedis in rats were induced by microcrystal monosodium urate (MSU) and the hyperuricemia model in rats was induced by adenine and ethambutol. The swelling rate, blood uric acid (UA) level, creatinine (Cr), blood urea nitrogen (BUN) level, and kidney indexes of rats were measured to screen antigout active fractions in Tongfeng Granule. Results: Fraction A (mainly consisting of flavonoids, alkaloids, and organic acids) in Tongfeng Granule showed the significant effect on gouty arthritis, gouty hyperuricemia with certain renal protection; It could significantly reduce the foot swelling rate (P < 0.01) and the contents of UA, Cr, and BUN in rats (P < 0.01); But compared with the model group, there was no significant difference in kidney indexes. Conclusion: Of all the fractions, fraction A has the highest inhibitory effects on inflammation and UA.