Research progress on role of mast cells in irritable bowel syndrome / 中国药理学通报

ABSTRACT

Irritable bowel syndrome (IBS) is one kind of functional gastrointestinal tract disorders with high incidence in the world. IBS is induced by avariety of factors,such as visceral hypersensitivity .abnormal gastrointestinal motility, intestinal barrier dysfunction, intestinal inflammation, neuro-immunity disorder, etc. The pathogenesis of IBS is complex and diverse. Mast cells (MCs) play an important role in the occurrence and development of IBS. The present article reviews the role of MCs both in the pathogenesis and in the treatment of IBS.