Summary of molecular mechanisms of spontaneous remission in gouty inflammation / 中国药理学通报

ABSTRACT

Acute gout subsides spontaneously within a certain period of time after onset, a process known as spontaneous remission of gouty inflammation. Its pathophysiological mechanism is related to the dynamic interaction of various components in the immune system, i. e. through the phagocytosis of autoimmune cells, the negative regulation of inflammatory mediators such as NLRP3 inflammasome, 1L-1R and Toll-like receptors, the recruitment of neutrophil extracellular traps at the site of crystal deposition and the formation of local chronic granuloma, to alleviate the necrotizing inflammation mediated by monosodium urate crystals. This review summarizes the molecular mechanism of spontaneous remission of gouty inflammation.