Advances in regulation of glyoxalase 1 expression in diseases / 中国药理学通报

ABSTRACT

Glyoxalase 1 (Glo 1) is an MG detoxification enzyme widely present in humans. It is highly conserved among different species and is closely related to the development of cancer, diabetes and nervous system diseases. In this paper, the expression and regulation of Glo lby the Glo 1 copy number variation (CNV), single nucleotide polymorphism (SNP), and transcription factor and non-coding RNA in the above diseases were summarized, aiming to deeply understand the role and the regulation of expression change rules of Glo 1 in the occurrence and development of diseases, so as to provide potential targets for disease prevention and treatment.