Regulation and mechanism of glucocorticoids on skeletal muscle metabolism / 中国药理学通报

ABSTRACT

Glucocorticoids ( GCs) have important regulatory effects on skeletal muscle metabolism. GCs can inhibit skeletal muscle glucose uptake and glycogen synthesis, and improve blood glucose levels by inhibiting Pik3rl expression, inhibiting insulin signaling pathway, or promoting pyruvate dehydrogenase kinase 4 expression; GCs can inhibit skeletal muscle lipid metabolism , causing the accumulation of lipid metabolism intermediates diacylglycerol and ceramides, and inducing skeletal muscle insulin resistance; GCs can induce MuRFl and MAFbx expression by promoting FoxO expression, activating the ubiquitin-proteasome system and autophagy lysosome system, and activating oxidative stress system, or promote the protein decomposi-tion of skeletal muscle by up-regulating C/EBPp expression; GCs can also inhibit the mTOR pathway by promoting myostatin and Pik3rl expression and inhibit skeletal muscle protein synthesis by up-regulating KLF-15 expression. This article explores the effects of GCs on skeletal muscle metabolism and its molecular mechanisms by tracking the latest developments at home and a-broad, which will provide reference for the clinical application of GCs.