Mechanism of dopaminergic neurotransmission on morphine addiction and stress depression / 中国药理学通报

ABSTRACT

Morphine addiction causes the disturbance in the dopaminergic transmission. The activity of dopaminergic neurons in patients with stress depression is reduced. These studies indicate a strong correlation between morphine addiction and stress depression, which involvement of one or more common neurobiological mechanisms. The dysfunction of dopaminergic neurotransmission from the ventral tegmental area(VTA) to the nucleus accumbens (NAc), prefrontal cortex (mPFC), amygdala (Amy), hippocampus (Hip), and striatum (ST) plays an important role in regulating morphine addiction and stress depression. This article summarizes the mechanism of the dopaminergic transmission regulating morphine addiction and stress depression.