Role of LncRNAs in cell senescence and therapeutic targets / 中国药理学通报

ABSTRACT

Long non-coding RNAs (LncRNAs) are non-coding RNAs with a length of more than 200 bp. Cellular senescence is a stable proliferative stagnation state, which is irreversible and may be caused by a variety of factors, such as telomere shortening, oncogene induction or oxidative stress. Multiple factors are involved in cellular senescence, in which p53/p21 and pl6/Rb are major regulators of cellular senescence in different cell types. Cellular aging has been extensively studied as a powerful tumor suppressor mechanism to counter the emergence of oncogenes. In this review, the mechanism of action and therapeutic targets of LncRNAs in senescent cells are explored in depth.