Effect of neferine on intracellular adriamycin accumulation in MCF-7 / Adr cell line / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 43-45, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-857421
ABSTRACT
AIM:
To study the effect of neferine on intracellular adriamycin (ADM) accumulation in MCF-7 / Adr cell line. METHODS The cytotoxic effect was determined by MTT assay. The intracellular ADM concentration was assayed by HPLC.RESULTS:
Neferine (Nef) decreased the IC50 of ADM to MCF-7 / Adr cells but increased the intracellular concentration of ADM.CONCLUSION:
The mechanism of the MDR reversal effect of Nef is associated with the increase of the intracellular accumulation of anticancer drug.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmacological Bulletin
Année:
2002
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS