Research advances in mechanism of doxorubicin-induced skeletal muscle dysfunction / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 314-320, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-857549
ABSTRACT
Doxorubicin(DOX) is a widely used clinical anti-tumor drug for cancer. Unfortunately, DOX can also cause skeletal muscle dysfunction in a dose-dependent manner, leading to a significant decline in the quality of life of cancer patients. In this paper, we summarize the toxic effects of DOX, the characteristics of DOX-induced skeletal muscle dysfunction and its related mechanisms. We focus on pathological mechanisms, including oxidative stress, Ca2+overload, mitochondrial energy metabolism disorder, autophagy and apoptosis, nitric oxide concentration and amino acid metabolism and myogenic regulatory factor expression. Research prospects are outlined. It is expected to provide a theoretical basis for the clinical study of DOX toxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Pharmacology and Toxicology
Année:
2019
Type:
Article
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