Advances in Research on the Effects of Wnt Pathway on Macrophage Function in Different Tissues / 中国药学杂志

ABSTRACT

Wnt protein is a group of highly conserved secretory signal molecules that regulate intercellular signal transduction during embryogenesis by autocrine or paracrine.Wnt signaling pathway is divided into β-catenin-dependent classical signaling pathway and non-classical signaling pathway, which is involved in cell proliferation, migration and differentiation. Macrophages are the main Wnt-secreting cells which are widely distributed in various tissues and participate in the development of many diseases. It is not clear how the Wnt signaling pathway plays a role in the development of macrophages.This article reviews the effects of Wnt signaling pathway on macrophage function in different tissues, and provides a theoretical basis for the diagnosis and treatment of related diseases.