Clinical Efficacy of Different Doses of Methylprednisolone Combined with Azithromycin in the Treatment of Severe Pulmonary Lobar Degeneration in Children with MP / 中国药学杂志

ABSTRACT

OBJECTIVE: To discuss the effect of different doses of methylprednisolone combined with azithromycin in the treatment of severe pulmonary lobar degeneration in children with MPP. METHODS: One hundred and twenty-eight children with severe MPP of pulmonary lobar degeneration were randomly divided into the low dose group and the high dose group with 64 cases in each group. The children of two groups were given azithromycin. On this basis, the children of low dose group were given conventional doses of methylprednisolone, the children of high dose group were given high-dose methylprednisolone. The clinical efficacy, immune function, inflammatory indexes and adverse reaction were compared.RESULTS: Compared with the low dose group, the disappearance time of cough, expectoration, wheezing and fever in the observation group was significantly shorter, the effective rate of the high dose group was significantly higher,the incidence of respiratory sequelae was significantly higher, the IL-2, IL-6, IL-13, TNF-α, IFN-γ in the observation group were significantly better (P0.05). CONCLUSION: Large dose of methylprednisolone combined with azithromycin can relieve the clinical symptoms of severe MPP in children with lobar degeneration. It also can promote the rehabilitation of the disease, effectively inhibit the inflammatory response of children and long-term sequelae, has the exact application value.