Development of f%T>MIC Calculation Model and Its Application in Individualized Medication Optimization of Carbopenems in Critical Care Patients / 中国药学杂志

ABSTRACT

OBJECTIVE: To develop the f%T>MIC computing model of carbapenems and adjust dose strategy based on the drug concentrations. METHODS: Pharmacokinetic equations within one time interval were deduced at steady state after multiple intravenous infusion. f%T>MIC calculator was compiled using EXCEL software and used for evaluation of antibiotic effect based on the concentrations at 0.5 and 3 h before administration of imipenem or meropenem at steady state. RESULTS: The calculation model can be used for f%T>MIC evaluation and dosage optimization. The model was used to determine f%T>MIC level of 107 ICU patients receiving imipenem or meropenem treatment. CONCLUSION: The present calculation model can provide a basis for the evaluation and optimization of dosage strategy,and it can be applied to other time-dependent antibiotics.