Game and Regulatory Suggestions in the Revision Process of Drug Instructions for Domestic Pharmaceutical Companies / 中国药学杂志

ABSTRACT

OBJECTIVE: To analyze the rational behaviors of pharmaceutical companies when modifying drug instructions, and puts forward policies and suggestions for promoting these enterprises to actively modify drug instructions. METHODS: The game theory is used to analyze the game equilibrium between enterprises and the market (patients and their agents -doctors) or the relevant government departments when they modify the instructions of the pharmaceutical enterprises in China. RESULTS: Based on cost considerations, enterprises are unwilling to modify drug instructions voluntarily. CONCLUSION: The drug regulatory departments in China should improve the relevant laws and regulations, and formulate specific operational drug instructions to modify the program.These measures would reduce the cost of enterprises to take the initiative to modify the drug instructions, and encourage the patient (and also be a doctor) to actively report the problem of adverse drug reactions caused by the unmodified instructions and increase penalties for not actively modify the behavior of drug instructions.At last the pharmaceutical companies could timely and actively modify instructions.