Identification of Chemical Constituents in Magnoliae Officinalis Cortex by UFLC-Triple TOF-MS/MS / 中国药学杂志

ABSTRACT

OBJECTIVE: To qualitatively analyze the major chemical constituents of Magnoliae Officinalis Cortex by UFLC-Triple TOF-MS/MS. METHODS: The analysis was carried out on an Agilent ZORBAX SB-C18 column(4.6 mm ×250 mm, 5 μm)with gradient elution of 0.1% formic acid-acetonitrile under both positive and negative ionization modes of ESI, respectively. The chemical components of Magnoliae Officinalis Cortex were identified by analyzing the accurate mass of molecular and product ions provided by UFLC-Triple TOF-MS/MS, comparison with reference standards and the literature data. RESULTS: A total of 24 compounds were identified or tentative presumed in Magnolia Officinalis Cortex, including 12 lignans, 9 alkaloids, and 3 phenylpropanoid glycosides. CONCLUSION: This study provides the foundation and support for study on material foundation of efficacy and the overall assessment of quality of Magnoliae Officinalis Cortex.