Preparation of Hispidulin Liposomes and Its Antitumor Effect in Vitro / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1624-1628, 2017.
Article
Dans Chinois
| WPRIM
| ID: wpr-858580
ABSTRACT
OBJECTIVE:
To study the preparing METHODS of hispidulin liposomes and evaluate their antitumor effects in vitro.METHODS:
Hispidulin liposomes were prepared by thin film dispersion method, and the formulation was further optimized. At the same time, the liposomes particle size and Zeta potential were characterized separately. The antiproliferative effect of the liposomes on A549 cells was investigated by sulforhodamine B(SRB) method.RESULTS:
According to the optimal prescription, the encapsulation efficiency of hispidulin liposomes was (87.06±0.67)%. Additionally, the average particle size was (104.83±1.40) nm and the Zeta potential was (-4.61±0.32) mV. Furthermore, the hispidulin liposomes exhibited the strongest inhibiting effect on A549 cells in vitro with comparison with control groups.CONCLUSION:
The preparation method builtin our research is easy. And the liposomes are well distributed with high encapsulation efficiency. Meanwhile, the hispidulin liposomes exhibit the most significant antitumor effects in vitro.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2017
Type:
Article
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