Processing Study of Epimedium Flavonoids Self-Assembled Micelles Fried with Suet Oil on Its Bioavailability / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the influence of bioavailability of Epimedium flavonoids after processing by suet oil. METHODS: Pharmacokinetics parameters of rats Epimedium flavonoids and icariin and baohuoside I was determining by the method of pharmacology effect and plasma concentration method. RESULTS: The concentration of the Epimedium flavonoids, icariin and baohuoside I in micelles groups were higher than that of the active pharmaceutical ingredient(API). ρmax were increased by 77.94%, 38.99% and 49.90%; AUC0-t increased by 95.19%, 37.76% and 43.49%; AUC0-∞ increased by 119.35%, 35.37% and 46.26% on Epimedium flavonoids, icariin and baohuoside I group. CONCLUSION: Suet oil improved the bioavailability of Epimedium flavonoids and promoted its absorption.