Preparation and Properties of Sulfadiazine Solid Dispersion / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 750-754, 2017.
Article
Dans Zh
| WPRIM
| ID: wpr-858723
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE: To prepare sulfadiazine solid dispersion, determine its solubility and dissolution in vitro, and investigate its physical properties. METHODS: Using in vitro dissolution as an index, single factor test and orthogonal design were used to optimize the preparation process of sulfadiazine solid dispersion. The existing state of sulfadiazine was identified by DSC, IR spectroscopy, and powder X-ray diffraction. RESULTS: The solubility and dissolution rate of sulfadiazine solid dispersion prepared by the optimized preparing process were increased by 17 times and 3 times respectively than crude sulfadiazine. Sulfadiazine existed in an amorphous state as shown by phase identification. CONCLUSION: The solid dispersion prepared by the solvent-molten method with PEG4000 as the carrier can significantly improve the solubility and the dissolution rate of sulfadiazine.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Prognostic_studies
langue:
Zh
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2017
Type:
Article