Analysis of the polymorphs of carbamazepin tablets by laser confocal micro-Raman spectrometer and establishment of the identification test model / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1690-1694, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-858959
ABSTRACT
OBJECTIVE:
To analyze the polymorphs of carbamazepin tablets by laser confocal micro-Raman spectrometer and establish the identification test model.METHODS:
Reference Raman spectra of the four crystal forms of carbamazepin were established; then the polymorphs of the carbamazepin tablets from different manufacturers were analyzed, and an identification test model was established to distinguish the unknown samples.RESULTS:
According to the results of the cluster analysis, the four batches of carbamazepin tablets from domestic manufacturers belonged to crystal form III. A qualitative model was created by choosing the first derivative and vector normalization method to process the spectra, using the factorization method to calculate, and selecting the 200-500, 650-850, 1 000-1 100, 1 500-1 700 cm-1 regions to compare. This model was verified to have high sensitivity, specificity, precisicion, negative prediction ability, and detection efficiency.CONCLUSION:
The laser confocal micro-Raman spectrometer canbe used to analyze the polymorphs of carbamazepin tablets and the qualitative identification is rapid and accurate.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude diagnostique
/
Étude pronostique
/
Recherche qualitative
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2016
Type:
Article
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