The decline of EPO in brain of aging rats induced by d-galactose effect and the reverse of the water extract of radix rehmanniae preparata / 中国药学杂志

ABSTRACT

OBJECTIVE: To observe the change of EPO in brain of aging rat induced by D-galactose (D-gal) and the EPO-based antiaging of the water extract of Radix Rehmanniae Preparata (WERRP). METHODS: D-gal-treated groups were received subcutaneous injection of D-gal at dose of 50, 150 and 250 mg·kg-1 daily for 8 weeks to imitate an aging model that was induced by oxidative stress. After the detection of EPO in hippocampus, the 150 mg