An exploring research about preparation technology and released effect of tamsulosion hydrochloride sustained-released capsules / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1586-1591, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-858973
ABSTRACT
OBJECTIVE:
To study the preparation technology of tamsulosion hydrochloride sustained-release capsules and investigate the release degree in vitro.METHODS:
The pellets containing tamsulosin hydrochloride were prepeared in the fluid-bed using bottom gush medicine. Then, it was coated with ethylcellulose aqueous dispersion (surelease), and in the following procedures, water-based acrylic resin enteric system (Acryl-EZE®) was used as coating material, hydroxypropylmethylcellulose E6 (HPMCE6) was considered as porous agent by fluid-bed. Based on the release degree in vitro, prescription influence factors were evaluated, as well as drug releases curve was compared, according to the single factor experiment.RESULTS:
The preparation technology referred in our research was available to make tamsulosin hydrochloride sustained-release capsules, and drug release curve of self-made sustained-release capsules was similar to the commercial one. Additionally, the products reproducibility of intra-batch and inter-batch was excellent.CONCLUSION:
The tamsulosin hydrochloride sustained-release capsules prepared in this study exhibited ideal sustained-release characteristics in vitro. The formulation is reasonable and feasible. It is suitable for industrial production.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2016
Type:
Article
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