Optimization of extraction process of Kangdu mixture / 中国药学杂志

ABSTRACT

OBJECTIVE: To select the optimum extracting procedure for Kangdu Mixture by the application of L9 (34). METHODS: Orthogonal design was used to observe and study the effects of the factors of water volume, extracting times and extracting time on kangdu Mixture, the chlorogenic Acid and yield of dry extract was determined by high performance liquid chromatography, the synthetic weighted mark method was used to evaluate the extraction process. RESULTS: The optimum water extraction is as follows; 10 times of water, extracting twice by relux, 2 hours for each time. CONCLUSION: The process choosed in this experiment is practicable and can be applied for preparation of Kangdu Mixture, the optimal process is simple and high precision.