Advances in the Interaction between Molecular Characteristics and Antimicrobial Activity of Carbapenem-Resistant Klebsiella pneumoniae / 中国药学杂志

ABSTRACT

Klebsiella pneumoniae, an important nosocomial infection pathogen, has high rate of clinical isolates. Carbapenems agents is stable for the majority β-lactamase initially, but with the broadly use of carbapenems agents, carbapenem resistant Klebsiella pneumoniae(CRKP) appear in hospital as a results, which result in the antibactic invalidation. With the CRKP rapiding growth in some area, the contents of the relevant literature review, in this article, the related literature content of the CRKP mechanism of drug resistance, molecular epidemiology and clinical antibiotic selection is reviewed, aims to explain the interaction between CRKP molecular characteristics and antimicrobial activity, also to provide theoretical basis for the more rational use of antimicrobial agents in the treatment of CRKP infection, and to investigate the CRKP different molecular mechanisms and antimicrobial activity relationship studies lay the theoretical foundation.