The load and sustained release performance of chloramphenicol in the poly(DMAM-co-AA) hydrogels / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the load capacity and slow releasing kinetics of chloramphenicol in poly(DMAM-co-AA) hydrogel based on N,N-dimethyl acrylamide (DMAM) and acrylic acid (AA). METHODS: The dry hydrogel was soaked in chloramphenicol solution, fully saturated and swelled. The load capacity of chloramphenicol in the swelled hydrogel was investigated. The dry gel loaded chloramphenicol was put into the different solution and constantly stirred. At the same time, the release rate of chloramphenicol was studied. RESULTS: When themole ratio of reaction monomers (DMAM/AA) and concentration of chloramphenicol solution were increased, the load capacityof chloramphenicol was increased. The release rate of chloramphenicol was increased with temperature rising. The release rate of chloramphenicolin acidic or alkaline medium was larger than that in neutral medium. CONCLUSION: The load capacity of chloramphenicol in poly(DMAM-co-AA) hydrogel is increased with the solution concentration of chloramphenicol increasing. The release of chloramphenicolin various hydrogels is completed in the range of 8 to 12 h, and the total release rate of chloramphenicol could reach about 90%.