Effect of inductive heating on drug release of tetrandrine-loaded PLGA magnetic nanoparticles / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare PLGA magnetic nanoparticles loaded with tetrandrine, heat the nanoparticles by inductive heating system, and study the particle size, morphology and drug release before and after heating. METHODS: Co-loaded PLGA NPs were prepared by emulsion solvent diffusion method; the physicochemical and magnetic characteristics of co-loaded PLGA NPs were investigated by DLS, SEM, TEM and VSM; RP-HPLC and ICP-MS analysis were used to measure the tetrandrine and Fe3O4 loading and entrapment efficiency. The EASYHEAT system was applied to heat the nanoparticles and further investigate the changes of particle size, morphology and drug release after inductive heating. RESULTS: Tetrandrine-loaded PLGA magnetic nanoparticles showed spherical shape with smooth surface and the Fe3O4 NPs were homogeneously distributed inside the polymeric nanoparticles; VSM result indicated that the co-loaded PLGA NPs were superparamagnetic; both tetrandrine and Fe3O4 showed good loading and entrapment efficiency. After being heated to 45℃, the diameter of co-loaded PLGA NPs increased; the morphology changed from a spherical shape into a nondefined, irregular shape; arrangement or aggregation of the incorporated Fe3O4 NPs were found. In addition, the drug release amount was also increased. CONCLUSION: With superparamagnetic property, the tetrandrine loaded-PLGA magnetic nanoparticles can effectively control the drug release behavior by inductive heating.