Advances in mitochondrial targeting molecules in anticancer applications / 中国药学杂志

ABSTRACT

In recent years, with the in-depth research on mitochondria, people realize that mitochondria have a vital role for apopto-sis of cancer cells. This finding promotes the development of mitochondrial targeting agents. Anticancer drugs modified with mitochondrial targeting molecules specifically acts on mitochondria and induce apoptosis of tumor cells to achieve targeting anti-tumor effect, so that the efficacy is improved while systemic toxicity of anticancer drugs is reduced. Mitochondrial targeting molecules have broad potential applications in anticancer drugs. This paper reviews the latest research progress of mitochondrial targeting molecules for cancer therapy, providing a reference for the treatment of cancer from the mitochondrial pathway.