Active monitoring of the hospital admissions due to adverse drug reactions in endocrinology ward / 中国药学杂志

ABSTRACT

OBJECTIVE: To obtain the prevalence of hospital admissions due to adverse drug reactions (ADRs) and study the main features of the ADRs. METHODS: The clinical data of the inpatients of endocrinology ward from January 2011 to December 2013 were collected by clinical pharmacists by interviewing with patients. And the types of ADRs, clinical features, suspicious drugs, hospital stays, cost and turnover were analyzed. RESULTS: Among the 6914 patients, 40 patients (0.58%) were hospitalized due to ADRs, including 13 males and 27 females. The mean age was (54.82±15.85) y. The mean hospital stay was (12.85±1.51) d. The mean cost was (10622.86±6719.48) Yuan. The 40 hospital admissions were attributed to 11 types of ADRs caused by 27 suspected drugs. The ADRs included hypoglycaemia, agranulocytosis (neutropenia), hypokalemic, hypophosphatemic osteomalacia secondary to renal tubular damage, electrolyte disturbances, elevated hepatenzyme, insulin allergy, insulin autoimmune syndrome, hypothyroidism, and hyperthyroidism. The suspicious drugs included antidiabetics(insulin, oral antidiabetics and traditional Chinese medicines), methimazole, adefovir and corticoids. CONCLUSION: The prevalence of hospital admission due to ADRs in the endocrinology ward was 0.47%. The clinical characteristics of the ADRs such as hypoglycaemia, hypokalemic and electrolyte disturbances were similar to the clinical manifestation of some endocrine system diseases, which might affect the diagnosis and delay the therapy. So, we should pay attention to ADRs during the process of diagnosis and therapy.