Concentrations of preoperative oral antofloxacin hydrochloride in patients after resection of lung tissue were analyzed / 中国药学杂志

ABSTRACT

OBJECTIVE: To determine the concentrationsof antofloxacin hydrochloride in the lung tissuesafter single dose preoperative oral administration of 400 mg in patientsreceiving pulmonry lobectomy for, preliminary evaluation of the rationality of this regimen to prevent infection. METHODS: Forty-eight patients with no clinical evidence of preoperative infection undergoing pulmonary lobectomy were selected and randomized into four treatment groups. 400 mg antofloxacin hydrochloride was administered orally at 4, 8, 12, and 24 h before the removal of the bronchi. Blood samples and lung tissues were collected after operation. The antofloxacin hydrochloride in blood serum and lung tissues was determined by high performance liquid chromatogram. RESULTS: The average concentrations of antofloxacin hydrochloride in serum andlung tissuesin the four groupswere (3.281±0.817)μg·mL-1 and (5.992±3.228)μg·g-1, (3.192±0.953)μg·mL-1 and (5.885 ±2.952)μg·g-1, (1.712 ±0.576) μg·mL-1 and (3.419±1.107)μg·g-1, and (0.431±0.095)μg·mL-1 and (1.258±0.306) μg·g-1, respectively. CONCLUSION: The clearance time of oral antofloxacin hydrochloride in lung tissue was longer than that in serum. Single dose administration of oral antofloxacin hydrochloride 400mg within 12 h before operation can achieve effective bactericidal levels in serum and lung tissues, which could be a method to prevent infection for pulmonary lobectomy.