Simultaneous determination of cyclosprine a, tacrolimus, sirolimus, mycophenolic acid, and prednisolone by UPLC-MS/MS / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish an UPLC-MS / MS method for simultaneous determination of a variety of drugs used for im¬munosuppressive therapy in the whole blood of renal transplant patients and to use this method for blood concentration monitoring in therapeutic drug monitoring.