Anti-tumor activity studies of vinorelbine tartrate liposome / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 1733-1736, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-860192
ABSTRACT
OBJECTIVE:
To explore the anti-tumor efficacy of liposomal vinorelbine tartrate injection(NVB-lipo).METHODS:
The anti-neoplastic effect of NVB-lipo was evaluated by using mice bearing H22 tumor and nude mice bearing NCI-H460 human xenograft tumor model.RESULTS:
After a single intravenous injection at doses of 20, 10, 5 and 2.5 mg · kg-1, the inhibition ratio of H22 tumor were 82.1%, 75.8%, 63.2% and 35.4% respectively, and that of NVB-free(20 and 10 mg · kg-1) were 45.8% and 37.1%. After three times iv injection interval 3-day, NVB-lipo 8 mg · kg-1 could markedly inhibited the growth of NCI-H460 tumor, relative to control and NVB-free (P < 0.05). The anti-tumor effect of NVB-lipo in H22 and NCI-H460 tumor model was much stronger than NVB-free, and was positively correlated with its dose levels.CONCLUSION:
At the same dose level, the antineoplastic effects of NVB-lipo is stronger than NVB-free.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2013
Type:
Article
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