Thermostability of fluconazole with different crystal forms / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 301-304, 2013.
Article
Dans Zh
| WPRIM
| ID: wpr-860477
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE:
To investigate the thermostability of four crystal forms of fluconazole.METHODS:
The thermostability of fluconazole was analyzed using XRD, DSC and TGA, and the structural characteristics of the crystal forms and crystalline transformation were determined using XRD with in-situ high temperature accessories.RESULTS:
The crystal form I and II had good at thermostability, and the crystal structure of form III changed at about 40°C. The monohydrate transformed to form II at about 70°.CONCLUSION:
The different crystal forms of fluconazole have distinct thermostability. The result of this study would provide a comprehensive reference for the quality evaluation of fluconazole.
Texte intégral:
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2013
Type:
Article