Study on the excretion of schizonepetin in rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the excretion profile of schizonepetin in rats. METHODS: An HPLC-UV method was developed and validated for the determination of schizonepetin in urine, feces and bile. Using this method, the excretion features were studied in rats after oral and intravenous administration. RESULTS: There was significant difference in the excretion percentages of schizonepetin between male and female both in rat urine and bile for oral administration and in urine for intravenous administration. No significant difference was observed in the excretion of schizonepetin through feces for the two administration routes. CONCLUSION: The amount of schizonepetin recovered from urine, feces and bile after administration is very low, indicating that schizonepetin is mainly excreted in the form of metabolites. Copyright 2012 by the Chinese Pharmaceutical Association.