Study on preparation technology of compound Danshen pulsatile release pellets / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 908-914, 2012.
Article
Dans Zh
| WPRIM
| ID: wpr-860721
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE: To prepare compound Danshen adhesion pulsatile release pellets. METHODS: Different coating materials were used. Swelling layer, controlled-release layer and adhesive layer were packed on drug-containing pellets from inside to outside. The coating effect on the dissolution was studied. The coating formulation was optimized. The adhesiveness of the pellets was e-valuated. RESULTS: The release delay and rate were affected by the materials of swelling layer, controlled-release layer and adhesive layer, the weight of coating layer, and the type and quantity of plasticizer. CONCLUSION: With the best coating prescription, a delay of 4.5 h in drug release was reached in simulated changing human gastrointestinal pH environment. The cumulative release reached more than 80% 1.5 h post the release lag, indicating a pulsatile release effect.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2012
Type:
Article