Effect of furazolidone on the pharmacokinetics of lansoprazole and its metabolites in rats / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 458-461, 2012.
Article
Dans Chinois
| WPRIM
| ID: wpr-860793
ABSTRACT
OBJECTIVE:
To evaluate the effect of furazolidone on the pharmacokinetics of lansoprazole in rats.METHODS:
Plasma concentrations of lansoprazole and its metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by HPLC-MS/ MS, and the pharmacokinetic parameters were calculated.RESULTS:
The pharmacokinetic parameters showed that furazolidone (40 mg · kg-1) remarkably increased the AUC0-4h of lansoprazole from (487.33 ± 122.40) to (779.82 ± 126.67) remarkably (P < 0.05), and significantly decreased the AUC0-4h ratios of lansoprazole sulfone/lansoprazole from (0.70 ± 0.34) to (0.33 ± 0.09) (P < 0.05).CONCLUSION:
Furazolidone inhibits the metabolism of lansoprazole via CYP3A4, and consequently improves the bioavailability of lansoprazole. Copyright 2012 by the Chinese Pharmaceutical Association.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Pharmaceutical Journal
Année:
2012
Type:
Article
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