Comparison on whole-body PET/CT and PET/MRI in diagnosis of adult lymphoma / 中国医学影像技术

ABSTRACT

Objective: To compare the diagnostic efficacy of PET/CT and PET/MRI for adult lymphoma. Methods: A total of 45 lymphoma patients who underwent systemic PET/CT and PET/MRI examinations. Data of PET/CT were evaluated by 2 readers independently, and PET/MRI were interpreted by 2 other readers,respectively. The maximal standardized uptake value (SUVmax), D value, D* value and f value corresponding to the maximum SUVmax were obtained, and the differences of diagnostic efficacy and staging of PET/CT and PET/MRI were analyzed. Results: Both PET/CT and PET/MRI detected SUVmax in 55 lymph nodes and 5 extra-node lesions. Thirty-nine lesions were identified on intravoxel incoherent motion (IVIM). For positive lesion detection, reader agreement was perfect between 2 readers and almost perfect between PET/CT and PET/MRI (k=0.956). For lymphoma staging, PET/CT was strongly consistent with PET/MRI (k=0.965). SUVmax from PET/CT and PET/MRI was significantly correlated (r=0.892, P<0.001), while weak correlation was demonstrated between D value and SUVmax (r=-0.312, P<0.050) and moderate correlation was demonstrated between f value and SUVmax (r=0.520, P<0.001). Conclusion: PET/MRI is comparable to PET/CT in diagnosis and staging in lymphoma, which can improve the accuracy of diagnosis and staging of lymphoma and moreover predict and evaluate the heterogeneity of tumor through combination of multiple parameters.