Gd-BOPTA-enhanced MRI evaluation of liver function in patients with cirrhosis / 中国医学影像技术

ABSTRACT

Objective: To investigate the relationship between liver function parameters and liver parenchymal relative enhancement (RE) at hepatocyte phase with gadobenate dimeglumine (Gd-BOPTA)-enhanced MRI, and to clarify clinical predictive factors affecting liver parenchymal RE.Methods: Data of 238 patients underwent abdominal Gd-BOPTA-enhanced MRI were retrospectively analyzed and classified into 4 groups, i.e. normal liver function group (NLF group) and liver cirrhosis Child-Pugh A, B and C group (LCA, LCB and LCC groups). Liver parenchymal RE at hepatocyte phase was calculated, and the relationship between liver parenchyma RE and liver function parameters were analyzed, then clarified clinical predictive factors affecting liver parenchymal RE. Results: Liver parenchyma RE of hepatocyte phase were negatively correlated with the changes of total bilirubin (TB), prothrombin time (PT), international normalized ratio (INR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and Child-Pugh classification (all P<0.01),but positively correlated with albumin (Alb) and cholinesterase (ChE) (both P<0.01). Liver parenchyma RE at hepatocyte phase in NLF group were significantly higher than that in LCA,LCB and LCC groups (all P<0.001), respectively, and lower in patients with ascites than in those without ascites (P<0.001). Compared with LCB and LCC groups, liver parenchyma RE at hepatocyte phase in LCA group were significantly higher (both P<0.001), and predicted factors of liver parenchymal RE in hepatocyte stage included TB, Alb, ALP, and presence of ascites. Conclusion: There are significant correlations of liver parenchyma RE and liver functional parameters in liver cirrhosis, predictive factors of liver parenchymal RE in hepatocyte stage with Gd-BOPTA-enhanced MRI include TB, Alb, ALP and presence of ascites.