Clinical Significance of NLR, PLR and MPV for Predicting Colorectal Adenomatous Polyp and Colorectal Cancer / 胃肠病学

ABSTRACT

Background: Many inflammatory markers have certain values in evaluating the prognosis of cancer patients, but studies on their diagnostic values for cancer and precancerous lesions are few. Aims: To explore the diagnostic significance of NLR, PLR and MPV for adenomatous polyp and colorectal cancer. Methods: Clinicopathological data of 198 patients with colorectal cancer (group A), 254 patients with adenomatous polyp (group B), 88 patients with non-adenomatous polyp (group C) diagnosed by endoscopic examination from September 2017 to July 2019 at Huludao Central Hospital were retrospectively analyzed, and 202 healthy subjects were served as controls (group D). WBC, NEU, LYM, PLT, MPV, NLR, PLR, CEA were compared among the four groups. ROC curve was used to evaluate the value of different parameters for diagnosing colorectal cancer and adenomatous polyp. Results: NLR, PLR, MPV had no relation with gender and age (P>0.05). WBC, NEU, PLT, NLR, PLR, CEA in group A were significantly increased when compared with group B, group C, group D (P<0.05), and LYM, MPV were significantly decreased (P<0.05). LYM, PLT in group B were significantly decreased when compared with group C (P<0.05), and NLR was significantly increased (P<0.05). WBC, NEU, NLR, CEA in group B were significantly increased when compared with group D (P<0.05), and PLT was significantly decreased (P<0.05). When the cut-off value was 1.93, 153.86, 10.55 fl, respectively, the AUC of NLR, PLR, MPV for diagnosing colorectal cancer were 0.877, 0.734, 0.704, respectively. The AUC of NLR combined with CEA for diagnosing colorectal cancer was 0.929, and the AUC of the combined NLR, PLR, MPV and CEA was 0.932. When the cut-off value was 1.62, the sensitivity of NLR for diagnosing adenomatous polyp was 68.1%, the specificity was 67.1%, AUC was 0.659, however, PLR and MPV had no significant value for diagnosing adenomatous polyp. Conclusions: NLR, PLR, MPV may have predicting value for detection of colorectal cancer, and combined with CEA can improve the efficacy. NLR may provide a new hematological screening method for detecting adenomatous polyp.