Gene Detection Improving Safety of Thiopurine Drugs in Treatment of Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Thiopurine drugs such as azathioprine and 6-mercaptopurine, are often used in the treatment of inflammatory bowel disease (IBD). However, patients treated with these drugs are prone to adverse drug reactions, in which myelosuppression is the most important and potentially fatal. Currently, multiple genetic markers have been used to identify patients with IBD who are sensitive to thiopurine drugs. This article reviewed the improving of safety of thiopurine drugs in treatment of IBD by gene detection.