Value of New Screening Scoring System of Gastric Cancer for Detecting Early Gastric Cancer Patients in Local Region / 胃肠病学

ABSTRACT

Background: The prognosis of early gastric cancer is significantly better than that of advanced gastric cancer. Because of the lacking of rational screening means, the detection rate of early gastric cancer is low. Serum pepsinogen Ⅰ (PGⅠ), PGⅡ, gastrin-17 (G-17) can be used for the screening of early gastric cancer. Aims: To investigate the value of new screening scoring system of gastric cancer for detecting patients with early gastric cancer in local region. Methods: A total of 393 patients from April 2017 to December 2018 were enrolled. According to pathological findings, patients were divided into control group, gastric ulcer group, dysplasia group and early gastric cancer group. Levels of PGⅠ, PGⅡ, G-17, Hp antibody were detected, and PGR was calculated. ROC curve was used to analyze the value of parameters for detecting early gastric cancer. Detection rates of early gastric cancer via serum ABC method, new ABC method and new screening scoring system were compared. Results: Compared with control group, serum PGⅠ and PGⅡ in gastric ulcer group were significantly increased, PGR was significantly decreased (P12.80 pmol/L and ≤6.90, respectively, the combination of these three indices for screening early gastric cancer had a sensitivity of 90.6%, specificity of 91.1%, and AUC of 0.965. The detection rate of early gastric cancer via new screening scoring system was significantly increased than that of serum ABC method, however, no significant difference was found between new screening scoring system and new ABC method (P>0.05). Conclusions: Decreased serum PGⅠ, PGR and increased G-17 may suggest the occurrence of early gastric cancer. New screening scoring system of gastric cancer is an efficient method for screening early gastric cancer.